Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238795 | 1.00 | CHRNA7 (0.57) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| SCHEMBL23207625 | 0.89 | CHRNA7 (0.50) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| SCHEMBL10238796 | 0.85 | CHRNA7 (0.45) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| SCHEMBL27894710 | 0.79 | CHRNA7 (0.55) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| SCHEMBL6845118 | 0.79 | CHRNA7 (0.55) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| SCHEMBL29649333 | 0.79 | CHRNA7 (0.55) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| Hydrochloric Acid SCHEMBL12983298 | 0.78 | CHRNA7 (0.54) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| Hydrochloric Acid SCHEMBL12983296 | 0.78 | CHRNA7 (0.54) | CHRNA7CHRNB2CHRNB4CHRNA4CHRNA2 | |
| SCHEMBL16692272 | 0.74 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4UHRF1 | |
| SCHEMBL14525626 | 0.72 | CHRNA7 (0.44) | CHRNA7UHRF1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076744-A1 | DISUBSTITUTED HETEROARYL-FUSED PYRIDINES | NOVARTIS AG (CH) | 2011-06-30 | — | — | WO | disclosed |