Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653590 | 0.90 | CYP11B2 (0.49) | MAPTCYP11B2CYP11B1KDM4EHTT | |
| SCHEMBL6659505 | 0.89 | HTR6 (0.50) | MAPTCYP11B2CYP11B1CYP19A1ROCK1 | |
| SCHEMBL6663540 | 0.85 | MAPT (0.44) | MAPTCYP11B2CYP11B1KDM4ECYP19A1 | |
| SCHEMBL6658554 | 0.85 | CYP19A1 (0.48) | MAPTCYP11B2CYP11B1KDM4ECYP19A1 | |
| SCHEMBL6840679 | 0.82 | CYP11B1 (0.52) | MAPTCYP11B2CYP11B1CYP19A1HTR6 | |
| SCHEMBL6661324 | 0.80 | HTR1D (0.46) | MAPTCYP11B2CYP11B1CYP17A1CYP19A1 | |
| SCHEMBL6659317 | 0.80 | CYP19A1 (0.45) | MAPTKDM4ECYP17A1CYP19A1HTR6 | |
| SCHEMBL6845500 | 0.78 | CYP11B1 (0.47) | MAPTCYP11B2CYP11B1CYP19A1HTR6 | |
| SCHEMBL6846187 | 0.76 | MAPT (0.40) | MAPTCYP11B2CYP11B1CYP17A1CYP19A1 | |
| SCHEMBL6659366 | 0.76 | CYP19A1 (0.47) | MAPTCYP11B2CYP11B1CYP19A1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | BAYER PHARMACEUTICALS CORPORATION | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | CYP17A1, IDO1, CYP21A2 | MAPT 1659/4885CYP11B2 53/4885CYP11B1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.