Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11207150 | 0.73 | ELANE (0.42) | ALDH1A1ELANE | |
| SCHEMBL10781415 | 0.71 | ELANE (0.41) | ALDH1A1ELANE | |
| SCHEMBL16878221 | 0.69 | — | — | |
| SCHEMBL922667 | 0.68 | ELANE (0.39) | ELANE | |
| SCHEMBL912750 | 0.68 | ELANE (0.52) | KDM4EALDH1A1ELANEHPGD | |
| SCHEMBL6849374 | 0.67 | — | — | |
| SCHEMBL923447 | 0.67 | ELANE (0.38) | ELANE | |
| SCHEMBL923606 | 0.64 | KDM4C (0.53) | KDM4EALDH1A1HTTNCOA1NCOA3 | |
| SCHEMBL13564437 | 0.63 | ELANE (0.39) | ELANE | |
| SCHEMBL5793353 | 0.63 | CHEK1 (0.50) | KDM4EALDH1A1HTTNCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446125-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | Alizyme Therapeutics Limited (GB) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003020282-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-03-13 | — | — | WO | disclosed |