⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849374 | 0.69 | — | — | |
| SCHEMBL6845558 | 0.69 | KDM4E (0.38) | — | |
| SCHEMBL941915 | 0.67 | CHRNB2 (0.48) | — | |
| SCHEMBL6119475 | 0.65 | CHRNB2 (0.47) | — | |
| Benzo[D]Oxazole SCHEMBL2311728 | 0.63 | NPC1 (0.37) | — | |
| Benzo[D]Oxazole SCHEMBL2724328 | 0.62 | — | — | |
| Benzo[D]Oxazole SCHEMBL7903 | 0.62 | — | — | |
| Benzo[D]Oxazole SCHEMBL27844655 | 0.62 | NPC1 (0.43) | — | |
| SCHEMBL452230 | 0.62 | — | — | |
| SCHEMBL210197 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12012467-B2 | Small molecule DCN1 inhibitors and therapeutic methods using the same | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-18 | — | — | US | disclosed |
| CN-110740996-B | Covalent small molecule DCN1 inhibitors and methods of treatment using the same | 密执安大学评议会 | 2024-01-09 | — | — | CN | disclosed |
| EP-3609876-B1 | COVALENT SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2022-03-30 | — | — | EP | disclosed |
| US-20200109167-A1 | SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2020-04-09 | — | — | US | disclosed |
| EP-3609876-A1 | COVALENT SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | The Regents of The University of Michigan (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3601245-A1 | SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | The Regents of The University of Michigan (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018191199-A1 | COVALENT SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-10-18 | — | — | WO | disclosed |
| US-20180289677-A1 | Covalent Small Molecule DCN1 Inhibitors and Therapeutic Methods Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2018-10-11 | — | — | US | disclosed |
| WO-2018183411-A1 | SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-10-04 | — | — | WO | disclosed |
| US-20160326157-A1 | MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-10 | — | — | US | disclosed |
| WO-2015103583-A1 | MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-07-09 | — | — | WO | disclosed |