Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849713 | 0.94 | CHRNA7 (0.43) | CHRNA7CHRM1CHRM3CHRM5CHRM2 | |
| SCHEMBL6849878 | 0.89 | CHRNA7 (0.40) | CHRNA7CHRM1CHRM3CHRM5CHRM2 | |
| SCHEMBL6849606 | 0.85 | CHRNA7 (0.40) | CHRNA7CHRM1CHRM3CHRM5CHRM2 | |
| SCHEMBL6848954 | 0.83 | CHRNA7 (0.43) | CHRNA7CHRM1CHRM3CHRM5CHRM2 | |
| SCHEMBL6845650 | 0.83 | CHRNA7 (0.42) | CHRNA7CHRM1CHRM3CHRM5CHRM2 | |
| SCHEMBL6849715 | 0.77 | CHRM1 (0.48) | CHRNA7CHRM1CHRM3CHRM5CHRM2 | |
| SCHEMBL6849534 | 0.73 | CHRNA7 (0.38) | CHRNA7 | |
| SCHEMBL6411769 | 0.71 | CHRNA7 (0.67) | CHRNA7 | |
| SCHEMBL6850187 | 0.69 | CHRNA7 (0.39) | CHRNA7 | |
| SCHEMBL5917886 | 0.68 | CHRNA7 (0.76) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476449-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070732-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |