Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.70 |
| ▸ | TDP2 | O95551 | 3/20 | 0.44 |
| ▸ | NSD2 | O96028 | 3/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845596 | 0.90 | TOP2A (0.56) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6846906 | 0.86 | TOP2A (0.72) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6846666 | 0.85 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6845597 | 0.85 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| Ascididemin SCHEMBL30547678 | 0.83 | TOP2A (1.00) | TOP2ATDP2NSD2PAX8ABL1 | |
| Ascididemin SCHEMBL6841381 | 0.83 | TOP2A (1.00) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6846950 | 0.82 | TOP2A (0.66) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6846896 | 0.82 | TOP2A (0.66) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL20259203 | 0.82 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL31237838 | 0.82 | TOP2A (0.66) | TOP2ATDP2NSD2PAX8ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202992-B1 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | CEPHALON FRANCE (FR) | 2004-09-15 | — | — | EP | claimed |
| EP-1202992-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | claimed |
| WO-2001012631-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | claimed |
| EP-1202992-B1 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | CEPHALON FRANCE (FR) | 2004-09-15 | — | — | EP | disclosed |
| EP-1202992-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012631-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |