Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.72 |
| ▸ | TDP2 | O95551 | 2/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.43 |
| ▸ | PADI1 | Q9ULC6 | 2/20 | 0.40 |
| ▸ | PADI3 | Q9ULW8 | 2/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.40 |
| ▸ | PADI2 | Q9Y2J8 | 2/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.40 |
| ▸ | S100A4 | P26447 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20259222 | 0.91 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL31237393 | 0.91 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6845499 | 0.90 | TOP2A (0.57) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6846666 | 0.86 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6845597 | 0.86 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6845707 | 0.86 | TOP2A (0.70) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL20259137 | 0.84 | TOP2A (0.51) | TOP2ACDC25BTERTMEN1KMT2A | |
| Ascididemin SCHEMBL6841381 | 0.84 | TOP2A (1.00) | TOP2ATDP2NSD2PAX8ABL1 | |
| Ascididemin SCHEMBL30547678 | 0.84 | TOP2A (1.00) | TOP2ATDP2NSD2PAX8ABL1 | |
| SCHEMBL6846896 | 0.83 | TOP2A (0.66) | TOP2ATDP2NSD2PAX8ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202992-B1 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | CEPHALON FRANCE (FR) | 2004-09-15 | — | — | EP | claimed |