Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 5/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846688 | 0.82 | GPR119 (0.43) | GPR119MAOBKCNH2HRH2HRH1 | |
| SCHEMBL6846770 | 0.80 | HRH2 (0.46) | GPR119HRH2HRH1L3MBTL1 | |
| SCHEMBL6848004 | 0.80 | HRH2 (0.62) | MAOBHRH2HRH1KAT6A | |
| SCHEMBL6846779 | 0.80 | HRH2 (0.44) | GPR119HRH2HRH1L3MBTL1 | |
| SCHEMBL6848230 | 0.80 | HRH2 (0.46) | GPR119HRH2HRH1L3MBTL1 | |
| SCHEMBL6847427 | 0.79 | HRH2 (0.62) | GPR119HRH2HRH1 | |
| SCHEMBL6983618 | 0.78 | HRH2 (0.61) | MAOBHRH2HRH1 | |
| SCHEMBL5220974 | 0.77 | P2RX7 (0.49) | HRH2HRH1 | |
| SCHEMBL6842221 | 0.77 | HRH2 (0.63) | MAOBHRH2HRH1 | |
| SCHEMBL5213475 | 0.75 | HRH2 (0.45) | MAOBKCNH2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467727-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059341-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-07-24 | — | — | WO | disclosed |