Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27320867 | 0.79 | HPGD (0.41) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL3543498 | 0.77 | NOTUM (0.33) | CHEK1 | |
| SCHEMBL3949727 | 0.76 | KDM4E (0.44) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL873201 | 0.75 | AKT2 (0.53) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL11362250 | 0.73 | KDM4E (0.60) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL1548731 | 0.73 | KDM4E (0.60) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL8684331 | 0.72 | MAPK1 (0.63) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL19288778 | 0.72 | KDM4E (0.44) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL570062 | 0.71 | PIN1 (0.47) | KDM4EHPGDALDH1A1HSD17B10TP53 | |
| SCHEMBL4961817 | 0.70 | NPC1 (0.41) | KDM4EHPGDALDH1A1HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397360-A1 | AZAINDOLES | Aventis Pharma Limited (GB) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000688-A1 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2003-01-03 | — | — | WO | disclosed |
| EP-1263759-A2 | AZAINDOLES | Aventis Pharma Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001047922-A2 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2001-07-05 | — | — | WO | disclosed |