Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | AKT2 | P31751 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | PRKDC | P78527 | 2/20 | 0.49 |
| ▸ | ILK | Q13418 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24114845 | 0.81 | IKBKB (0.68) | MAPK1NPSR1IKBKBKMT2AALDH1A1 | |
| SCHEMBL21711385 | 0.81 | IKBKB (0.58) | MAPK1NPSR1IKBKBKMT2AALDH1A1 | |
| SCHEMBL873201 | 0.79 | AKT2 (0.53) | MAPK1NPSR1KMT2AAKT2ALDH1A1 | |
| SCHEMBL2949076 | 0.79 | KDM4E (0.68) | MAPK1NPSR1KMT2AAKT2ALDH1A1 | |
| SCHEMBL11362250 | 0.78 | KDM4E (0.60) | MAPK1NPSR1AKT2ALDH1A1KDM4E | |
| SCHEMBL5820038 | 0.78 | MAPK1 (1.00) | MAPK1NPSR1KMT2AAKT2ALDH1A1 | |
| SCHEMBL1548731 | 0.78 | KDM4E (0.60) | MAPK1NPSR1AKT2ALDH1A1KDM4E | |
| SCHEMBL21711439 | 0.77 | IKBKB (0.54) | MAPK1NPSR1IKBKBALDH1A1GAA | |
| SCHEMBL6132022 | 0.77 | MAPK1 (0.80) | MAPK1NPSR1IKBKBKMT2AAKT2 | |
| SCHEMBL2875437 | 0.76 | MAPK1 (0.63) | MAPK1NPSR1IKBKBKMT2AAKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230065629-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2023-03-02 | — | — | US | disclosed |
| US-11208400-B2 | Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof | BAYER AKTIENGESELLSCHAFT (DE) | 2021-12-28 | — | — | US | disclosed |
| EP-3526212-B1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AG (DE) | 2021-12-22 | — | — | EP | disclosed |
| US-20200055842-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2020-02-20 | — | — | US | disclosed |
| US-5723481-A | ANTIULCER AGENTS AND 5-LIPOXYGENASE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| US-5698576-A | POSSESS ANTI-ULCER AND 5-LIPOXYGENASE INHIBITORY ACTIVITIES | SANKYO COMPANY, LIMITED (JP) | 1997-12-16 | — | — | US | disclosed |
| US-5665752-A | LIPOXYGENASE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1997-09-09 | — | — | US | disclosed |
| CN-1034333-C | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1997-03-26 | — | — | CN | disclosed |
| CN-1032207-C | Imidazopyrazole derivatives useful as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1996-07-03 | — | — | CN | disclosed |
| CN-1094049-A | Be used as the preparation method of the imidazolopyrazole derivatives of anodyne and antiphlogistic | SANKYO CO (JP) | 1994-10-26 | — | — | CN | disclosed |
| US-5354768-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-11 | — | — | US | disclosed |
| EP-0353047-B1 | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1994-10-05 | — | — | EP | disclosed |
| US-5232939-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO COMPANY LIMITED (JP) | 1993-08-03 | — | — | US | disclosed |
| CN-1040196-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1990-03-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11208400-B2 | Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof | REN, ATP6V1B1, GLS | MAPK1 3377/4885NPSR1 3319/4885IKBKB 650/4885 |
| US-20200055842-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | REN, ATP6V1B1, GLS | MAPK1 3377/4885NPSR1 3319/4885IKBKB 650/4885 |
| US-20230065629-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | REN, ATP6V1B1, GLS | MAPK1 3377/4885NPSR1 3319/4885IKBKB 650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.