Avobenzone

Avobenzone

SCHEMBL6846873

COc1ccc(C(=O)CC(=O)c2ccc(C(C)(C)C)cc2)cc1.c1ncncn1

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.85
LMNA P02545 2/20 0.85
ALOX15 P16050 1/20 0.85
APEX1 P27695 1/20 0.85
MAPK1 P28482 1/20 0.85
RECQL P46063 1/20 0.85
HSD17B10 Q99714 1/20 0.85
TDP1 Q9NUW8 1/20 0.85
MAPT P10636 3/20 0.63
NPC1 O15118 3/20 0.58
RAB9A P51151 2/20 0.58
MEN1 O00255 1/20 0.58
EPHX2 P34913 1/20 0.58
KMT2A Q03164 1/20 0.58
NR1H4 Q96RI1 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
CA1 P00915 2/20 0.49
CA2 P00918 2/20 0.49
GSK3B P49841 1/20 0.49
HDAC3 O15379 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Avobenzone SCHEMBL15650 0.92 ALDH1A1 (1.00) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL1768910 0.92 ALDH1A1 (1.00) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL16506197 0.91 ALDH1A1 (0.97) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL5680371 0.87 TDP1 (0.88) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL2526688 0.87 LMNA (0.88) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL2037563 0.87 ALDH1A1 (0.88) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL28862533 0.84 ALDH1A1 (0.83) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL28842232 0.83 ALDH1A1 (0.81) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL21239896 0.83 ALDH1A1 (0.81) ALDH1A1LMNAALOX15APEX1MAPK1
Avobenzone SCHEMBL28576597 0.83 ALDH1A1 (0.81) ALDH1A1LMNAALOX15APEX1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6776980-B1 SUNSCREEN AGENTS FOR HUMAN SKIN AND/OR HAIR AGAINST ULTRAVIOLET AND SOLAR RADIATION L'OREAL (FR) 2004-08-17 US disclosed
US-5928629-A SUNSCREEN AGENT CONSISTS OF 4-TERT-BUTYL-4'-METHOXYDIBENZOYLMETHANE, 1,3,5-TRIAZINE COMPOUND, AND ALKYL BETA, BETA-DIPHENYLACRYLATE OR ALKYL ALPHA-CYANO-BETA-BETA-DIPHENYLACRYLATE COMPOUND SOCIETE L'OREAL S.A. (FR) 1999-07-27 US disclosed