Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847686 | 1.00 | RHOA (0.55) | RHOARAB9ASMN1; SMN2PAX8NPC1 | |
| SCHEMBL16826886 | 0.82 | RAB9A (0.51) | RHOARAB9ASMN1; SMN2PAX8NPC1 | |
| SCHEMBL16826884 | 0.82 | RAB9A (0.51) | RHOARAB9ASMN1; SMN2PAX8NPC1 | |
| SCHEMBL525672 | 0.78 | PDE10A (0.50) | RAB9ASMN1; SMN2PAX8NPC1ALDH1A1 | |
| SCHEMBL372181 | 0.76 | KDM4E (0.58) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL5099480 | 0.76 | KDM4E (0.58) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL12923109 | 0.76 | PAX8 (0.63) | RAB9ASMN1; SMN2PAX8NPC1ALDH1A1 | |
| SCHEMBL6852218 | 0.76 | RAB9A (0.50) | RAB9ASMN1; SMN2PAX8NPC1ALDH1A1 | |
| SCHEMBL7940364 | 0.76 | RAB9A (0.50) | RAB9ASMN1; SMN2PAX8NPC1ALDH1A1 | |
| SCHEMBL6852382 | 0.76 | RAB9A (0.50) | RAB9ASMN1; SMN2PAX8NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |