Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852009 | 0.78 | NPC1 (0.45) | ALDH1A1RAB9AKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL27720626 | 0.76 | CYP1A2 (0.49) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL529903 | 0.76 | CYP1A2 (0.44) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL12505007 | 0.75 | PDGFRB (0.46) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL409414 | 0.74 | CYP1A2 (0.42) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL4065530 | 0.74 | CYP1A2 (0.48) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL5462379 | 0.73 | CYP1A2 (0.44) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL15194838 | 0.71 | NQO1 (0.43) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL29800505 | 0.70 | CYP1A2 (0.44) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL372069 | 0.70 | CYP1A2 (0.44) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |