Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720626 | 0.78 | CYP1A2 (0.49) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL529903 | 0.78 | CYP1A2 (0.44) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL12505007 | 0.76 | PDGFRB (0.46) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL1994037 | 0.74 | CYP1A2 (0.45) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL6848110 | 0.74 | CYP1A2 (0.41) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL15194838 | 0.72 | NQO1 (0.43) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL5462379 | 0.71 | CYP1A2 (0.44) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL9373270 | 0.71 | CYP1A2 (0.45) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL530808 | 0.71 | CYP1A2 (0.45) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 | |
| SCHEMBL27046185 | 0.71 | CYP1A2 (0.45) | CYP1A2PDGFRBPDGFRAMGAMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1370148-A | Process for the preparation of quinoline-substituted carbonate and carbamate derivatives | ABBOTT LAB (US) | 2002-09-18 | — | — | CN | claimed |
| US-8324173-B2 | Peptides useful as dual caspase-2/-6 inhibitors and their biological applications | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-12-04 | — | — | US | disclosed |
| US-20120021990-A1 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | CHAUVIER DAVID (FR) | 2012-01-26 | — | — | US | disclosed |
| US-20090042805-A1 | Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-02-12 | — | — | US | disclosed |
| EP-1817328-A2 | NEW PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | Theraptosis S.A. (FR) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006056487-A2 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | THERAPTOSIS S.A. (FR) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042805-A1 | Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications | CASP6, CASP2, CASP4 | CYP1A2 2148/4885PDGFRB 4286/4885PDGFRA 4451/4885 |
| US-20120021990-A1 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | CASP6, CASP2, CASP1 | CYP1A2 4555/4885PDGFRB 2958/4885PDGFRA 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.