SCHEMBL6848416

SCHEMBL6848416

CC(C)(C)OC(=O)NCCc1ccc2cc[nH]c2c1.O=Cc1ccc2cc[nH]c2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.50
NQO2 P16083 1/20 0.41
NAMPT P43490 1/20 0.41
MAPT P10636 5/20 0.40
APP P05067 3/20 0.40
BACE1 P56817 1/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
IGF1R P08069 1/20 0.38
NLRP3 Q96P20 2/20 0.37
BCHE P06276 1/20 0.37
AKT1 P31749 1/20 0.36
IDO1 P14902 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
PTGER4 P35408 1/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GLA P06280 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6328558 0.91 NQO2 (0.47) NQO2NAMPTMAPTBACE1CA1
SCHEMBL30937471 0.82 HDAC1 (0.48) NQO2NAMPTMAPTCA1CA2
SCHEMBL1615764 0.80 NLRP3 (0.52) NAMPTMAPTNLRP3TDP1GAA
SCHEMBL30193348 0.80 NLRP3 (0.52) NAMPTMAPTNLRP3TDP1GAA
SCHEMBL693427 0.79 CA2 (0.53) NQO2NAMPTMAPTCA1CA2
SCHEMBL698405 0.77 NQO2 (0.49) NQO2NAMPTMAPTCA1CA2
SCHEMBL1586042 0.74 CA12 (0.55) NQO2MAPTCA1CA2BCHE
SCHEMBL30937476 0.73 PIM1 (0.46) NQO2NAMPTMAPTCA1CA2
SCHEMBL18544334 0.72 CA12 (0.55) NQO2MAPTCA1CA2BCHE
SCHEMBL25495856 0.72 CA2 (0.48) NQO2NAMPTMAPTAPPCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1250334-B1 Medicaments useful for the treatment of proliferative diseases LILLY CO ELI (US) 2004-05-19 EP disclosed
EP-1250334-A2 AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES ELI LILLY AND COMPANY (US) 2002-10-23 EP disclosed
EP-1242420-A2 AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES ELI LILLY AND COMPANY (US) 2002-09-25 EP disclosed
WO-2001044235-A2 AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES ELI LILLY AND COMPANY (US) 2001-06-21 WO disclosed
WO-2001044247-A2 AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES ELI LILLY AND COMPANY (US) 2001-06-21 WO disclosed