Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 12/20 | 0.58 |
| ▸ | TACR2 | P21452 | 10/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | TRPV4 | Q9HBA0 | 8/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855974 | 0.90 | TACR3 (0.70) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL2373330 | 0.85 | TRPV4 (0.72) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| Hydrochloric Acid SCHEMBL5733490 | 0.84 | TRPV4 (0.71) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL6853726 | 0.84 | TACR3 (0.60) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL4236971 | 0.82 | TACR3 (0.85) | TACR3TACR2KCNH2 | |
| SCHEMBL6200694 | 0.82 | TACR2 (0.51) | TACR3TACR2OPRM1TRPV4 | |
| SCHEMBL6200702 | 0.82 | TACR2 (0.51) | TACR3TACR2OPRM1TRPV4 | |
| SCHEMBL6202262 | 0.82 | TACR2 (0.51) | TACR3TACR2OPRM1TRPV4 | |
| SCHEMBL6853853 | 0.82 | TRPV4 (0.62) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL5733751 | 0.80 | TACR3 (0.62) | TACR3TACR2OPRM1KCNH2TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | claimed |
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |