Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9126978 | 0.98 | ALDH1A1 (0.69) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL9126998 | 0.92 | ALDH1A1 (0.69) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL9187129 | 0.88 | ALDH1A1 (0.67) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL9126567 | 0.84 | ALDH1A1 (0.61) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL1834517 | 0.84 | RAB9A (0.65) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL9126667 | 0.82 | ALDH1A1 (0.60) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL1012812 | 0.82 | CYP1A2 (0.65) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL27836777 | 0.82 | KMT2A (0.62) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL23240070 | 0.81 | ALDH1A1 (0.67) | ALDH1A1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL9187138 | 0.81 | ALDH1A1 (0.67) | ALDH1A1GAAHTTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1394152-A1 | 2-IMINOIMIDAZOLE DERIVATIVES (1) | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |