Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11844378 | 0.78 | CA2 (0.45) | CHRM2CHRM1CHRM4CHRM3SLC18A3 | |
| SCHEMBL11839957 | 0.76 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3CYP2D6 | |
| SCHEMBL11840038 | 0.75 | CHRM2 (0.46) | CHRM2CHRM1CHRM4CHRM3SLC18A3 | |
| SCHEMBL25005887 | 0.72 | CHRM2 (0.64) | CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL22006156 | 0.72 | CHRM2 (0.47) | CHRM2CHRM1CHRM4CHRM3CYP2D6 | |
| SCHEMBL28522654 | 0.72 | CHRM2 (0.47) | CHRM2CHRM1CHRM4CHRM3CYP2D6 | |
| SCHEMBL13079825 | 0.72 | CHRM2 (0.47) | CHRM2CHRM1CHRM4CHRM3CYP2D6 | |
| SCHEMBL17807032 | 0.72 | CHRM2 (0.47) | CHRM2CHRM1CHRM4CHRM3CYP2D6 | |
| SCHEMBL11836124 | 0.70 | NAAA (0.55) | CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL6429689 | 0.70 | CHRM2 (0.45) | CHRM2CHRM1CHRM4CHRM3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| EP-0865439-A4 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0865439-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1996040672-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |