Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20512889 | 0.93 | BRD4 (0.41) | BRD4CHRNB2CHRNA4HTTCYP1A2 | |
| SCHEMBL8418298 | 0.81 | BRD4 (0.44) | BRD4CHRNB2CHRNA4CYP1A2GRM4 | |
| SCHEMBL31289217 | 0.78 | IDO1 (0.40) | — | |
| SCHEMBL14561784 | 0.78 | CHRNB2 (0.44) | BRD4CHRNB2CHRNA4CYP1A2GRM4 | |
| SCHEMBL14561721 | 0.78 | CHRNB2 (0.41) | BRD4CHRNB2CHRNA4CYP1A2GRM4 | |
| SCHEMBL6850450 | 0.78 | CHRNB2 (0.41) | BRD4CHRNB2CHRNA4CYP1A2GRM4 | |
| SCHEMBL17307553 | 0.78 | BRD4 (0.41) | BRD4CHRNB2CHRNA4 | |
| SCHEMBL17215283 | 0.78 | ESR1 (0.42) | BRD4CHRNB2CHRNA4CYP1A2GRM4 | |
| SCHEMBL31716440 | 0.77 | GRM4 (0.33) | GRM4 | |
| SCHEMBL8256637 | 0.77 | BRD4 (0.48) | BRD4CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019062802-A1 | ISOXAZOLINE DERIVATIVES AND THEIR USES IN AGRICULTURE RELATED APPLICATION | DONGGUAN HEC TECH R & D CO., LTD. (CN) | 2019-04-04 | — | — | WO | disclosed |
| EP-2462144-B1 | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE | MERCK SHARP & DOHME (US) | 2017-09-20 | — | — | EP | disclosed |
| US-20120220769-A1 | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE | SCHERING CORPORATION (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220769-A1 | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE | SCHERING CORPORATION (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2011017299-A2 | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE | SCHERING CORPORATION (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220769-A1 | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE | UMPS, AZI2, TYMS | BRD4 997/4885CHRNB2 3616/4885CHRNA4 2229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.