SCHEMBL6850757

SCHEMBL6850757

OC/C=C/c1ccc(-n2cccn2)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
MAPT P10636 3/20 0.41
KDM4E B2RXH2 2/20 0.41
MEN1 O00255 2/20 0.41
GAA P10253 2/20 0.41
KMT2A Q03164 2/20 0.41
LMNA P02545 1/20 0.41
G6PD P11413 1/20 0.41
CYP3A4 P08684 1/20 0.40
RECQL P46063 1/20 0.40
MAPK1 P28482 3/20 0.37
ACLY P53396 2/20 0.37
NAMPT P43490 1/20 0.36
JAK2 O60674 1/20 0.36
TYK2 P29597 1/20 0.36
IRAK4 Q9NWZ3 1/20 0.35
KCNN4 O15554 1/20 0.35
KCNA5 P22460 1/20 0.35
OPRM1 P35372 1/20 0.34
OPRD1 P41143 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6850761 1.00 ALDH1A1 (0.41) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6854067 0.82 ALDH1A1 (0.40) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6850814 0.81 IRAK4 (0.46) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6850818 0.81 IRAK4 (0.46) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6880930 0.80 ALDH1A1 (0.40) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6852283 0.80 ALDH1A1 (0.40) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6852285 0.80 ALDH1A1 (0.40) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6876904 0.80 ALDH1A1 (0.44) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL6876899 0.80 ALDH1A1 (0.44) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL1610526 0.79 ALDH1A1 (0.57) ALDH1A1MAPTKDM4EMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed