Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852283 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6880930 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6881690 | 0.83 | USP9X (0.38) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6881693 | 0.83 | USP9X (0.38) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6881700 | 0.83 | USP9X (0.38) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6850761 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6850757 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6852346 | 0.79 | KDM4E (0.55) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6852339 | 0.79 | KDM4E (0.55) | ALDH1A1KDM4EMEN1GAAKMT2A | |
| SCHEMBL6852332 | 0.79 | KDM4E (0.55) | ALDH1A1KDM4EMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |