Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 7/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.33 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850925 | 0.78 | HDAC4 (0.40) | MAPTCYP19A1HDAC1PIM1HDAC4 | |
| SCHEMBL6850500 | 0.76 | OPRD1 (0.41) | LMNAERN1CYP19A1SMN1; SMN2MAPK1 | |
| SCHEMBL6850619 | 0.74 | LTA4H (0.41) | HDAC4 | |
| SCHEMBL7488096 | 0.72 | CYP2D6 (0.39) | LMNAMAPK1 | |
| SCHEMBL24871307 | 0.67 | MAPT (0.61) | MAPTLMNACYP17A1CYP3A4CYP19A1 | |
| SCHEMBL26923851 | 0.67 | MAPT (0.61) | MAPTLMNAERN1CYP17A1CYP3A4 | |
| SCHEMBL6853889 | 0.66 | OGA (0.35) | MAPTSMN1; SMN2DYRK1ADYRK1B | |
| SCHEMBL10000032 | 0.66 | MAPT (0.92) | MAPTLMNACYP3A4NOTUMKIF11 | |
| SCHEMBL135626 | 0.66 | MAPT (0.92) | MAPTLMNACYP3A4NOTUMKIF11 | |
| Formic Acid SCHEMBL16673124 | 0.64 | MAPT (0.65) | MAPTLMNAERN1NOTUMKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |