Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 16/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6008395 | 0.86 | CHRNA7 (0.52) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL6849156 | 0.86 | CHRNA7 (0.39) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL6844331 | 0.84 | CHRNA7 (0.37) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL6844277 | 0.83 | CHRNA7 (0.41) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL6007579 | 0.80 | CHRNB2 (0.40) | CHRNA7HTR3ACNR2 | |
| SCHEMBL6850944 | 0.80 | CNR2 (0.37) | CHRNA7CNR2 | |
| SCHEMBL6848361 | 0.79 | GPBAR1 (0.39) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL6848991 | 0.75 | GABRA1 (0.35) | CNR2 | |
| SCHEMBL6849468 | 0.73 | CHRNA7 (0.38) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL6850864 | 0.73 | CHRNA7 (0.36) | HTR3EHTR3BCHRNA7HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406901-A1 | QUINUCLIDINES-SUBSTITUTED-MULTI-CYCLIC-HETEROARYLS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-14 | — | — | EP | claimed |
| WO-2002100857-A1 | QUINUCLIDINES-SUBSTITUTED-MULTI-CYCLIC-HETEROARYLS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-19 | — | — | WO | claimed |
| EP-1406901-A1 | QUINUCLIDINES-SUBSTITUTED-MULTI-CYCLIC-HETEROARYLS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2002100857-A1 | QUINUCLIDINES-SUBSTITUTED-MULTI-CYCLIC-HETEROARYLS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |