Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.54 |
| ▸ | RAB9A | P51151 | 9/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544356 | 0.79 | KCNH2 (0.54) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL1543918 | 0.75 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL10094557 | 0.73 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL1544817 | 0.71 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL1543815 | 0.69 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL1543652 | 0.66 | KCNH2 (0.55) | NPC1RAB9ASMN1; SMN2MAPTPOLB | |
| SCHEMBL1544620 | 0.65 | KCNH2 (0.68) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL1544309 | 0.65 | KCNH2 (0.53) | NPC1RAB9ATP53POLBGRM5 | |
| SCHEMBL12652838 | 0.64 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2TP53NFKB1 | |
| SCHEMBL5760555 | 0.64 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040152699-A1 | Compounds | ASTRAZENECA AND NPS PHARMACEUTICALS, INC. | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152699-A1 | Compounds | SDHA, CYP11B2, CYP11B1 | NPC1 6/4885RAB9A 1283/4885SMN1; SMN2 2060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.