Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6417110 | 0.82 | CHRNA7 (0.44) | NAMPTCHRNA7KDM4E | |
| SCHEMBL6851401 | 0.71 | — | — | |
| SCHEMBL6413063 | 0.70 | CHRNA7 (0.41) | CHRNA7 | |
| SCHEMBL6415882 | 0.70 | CHRNA7 (0.40) | CHRNA7 | |
| SCHEMBL21063818 | 0.69 | HDAC2 (0.57) | — | |
| SCHEMBL6419147 | 0.68 | CHRNA7 (0.41) | CHRNA7KDM4E | |
| SCHEMBL6418898 | 0.68 | EPHX2 (0.40) | CHRNA7CHRM3 | |
| SCHEMBL6419159 | 0.68 | CHRNA7 (0.38) | CHRNA7 | |
| SCHEMBL6413482 | 0.67 | NAMPT (0.45) | NAMPTCHRNA7 | |
| SCHEMBL30147455 | 0.67 | HDAC8 (0.44) | CHRNA7HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476449-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070732-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |