Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 6/20 | 0.33 |
| ▸ | CNR1 | P21554 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037197 | 0.79 | DPP4 (0.35) | PTGDR2CNR2CNR1MEN1CYP2C9 | |
| SCHEMBL7675734 | 0.74 | MCL1 (0.41) | PTGDR2ALDH1A1 | |
| SCHEMBL6850299 | 0.73 | KDM4E (0.38) | PTGDR2MEN1CYP2C9KMT2A | |
| SCHEMBL6851617 | 0.72 | PTGDR2 (0.34) | PTGDR2CNR2CNR1MEN1KMT2A | |
| SCHEMBL6847665 | 0.71 | PTGDR2 (0.33) | PTGDR2MEN1KMT2AALDH1A1 | |
| SCHEMBL6490814 | 0.70 | MEN1 (0.47) | PTGDR2MEN1CYP3A4KMT2ANPC1 | |
| SCHEMBL7038582 | 0.63 | HTR2C (0.48) | MAPTPTGDR2MEN1KMT2AALDH1A1 | |
| SCHEMBL7673579 | 0.62 | HTR2A (0.38) | PTGDR2 | |
| SCHEMBL7673368 | 0.62 | HTR2C (0.41) | PTGDR2 | |
| SCHEMBL6491761 | 0.61 | CHRM1 (0.38) | PTGDR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173440-B1 | TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS | UPJOHN CO (US) | 2004-09-15 | — | — | EP | claimed |