Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.34 |
| ▸ | FABP4 | P15090 | 6/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847665 | 0.79 | PTGDR2 (0.33) | PTGDR2FABP4FABP3MEN1ALDH1A1 | |
| SCHEMBL7672109 | 0.75 | HTR2C (0.39) | PTGDR2FABP4MEN1ALDH1A1KMT2A | |
| SCHEMBL6850299 | 0.73 | KDM4E (0.38) | PTGDR2FABP4FABP3MEN1KMT2A | |
| SCHEMBL6851622 | 0.72 | LTB4R (0.37) | PTGDR2MEN1ALDH1A1KMT2ACNR1 | |
| SCHEMBL6491761 | 0.70 | CHRM1 (0.38) | PTGDR2ENPP2CNR1 | |
| SCHEMBL6495688 | 0.69 | MEN1 (0.47) | PTGDR2SMN1; SMN2MEN1ALDH1A1HTT | |
| SCHEMBL7037197 | 0.67 | DPP4 (0.35) | PTGDR2FABP4FABP3MEN1ALDH1A1 | |
| SCHEMBL6851523 | 0.66 | HTR2A (0.39) | PTGDR2FABP4CNR1 | |
| SCHEMBL6496372 | 0.66 | PTGDR2 (0.36) | PTGDR2FABP4MEN1ALDH1A1KMT2A | |
| SCHEMBL6485143 | 0.66 | HTR2C (0.46) | PTGDR2FABP4MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173440-B1 | TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS | UPJOHN CO (US) | 2004-09-15 | — | — | EP | claimed |