Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 3/20 | 0.35 |
| ▸ | FABP3 | P05413 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491761 | 0.82 | CHRM1 (0.38) | PTGDR2HTR2B | |
| SCHEMBL7037197 | 0.74 | DPP4 (0.35) | PTGDR2MEN1KMT2AFABP4FABP3 | |
| SCHEMBL6496231 | 0.74 | SMN1; SMN2 (0.50) | PTGDR2MEN1KMT2AGRIN2BCYP2C19 | |
| SCHEMBL6851617 | 0.73 | PTGDR2 (0.34) | PTGDR2MEN1KMT2AFABP4FABP3 | |
| SCHEMBL6851622 | 0.73 | LTB4R (0.37) | PTGDR2MEN1KMT2ACYP2C9 | |
| SCHEMBL6847665 | 0.72 | PTGDR2 (0.33) | PTGDR2MEN1KMT2AFABP4FABP3 | |
| SCHEMBL7030588 | 0.72 | MCL1 (0.52) | KDM4ETDP1MEN1KMT2ACYP2C9 | |
| SCHEMBL6485143 | 0.68 | HTR2C (0.46) | KDM4ETDP1PTGDR2MEN1KMT2A | |
| SCHEMBL6496372 | 0.66 | PTGDR2 (0.36) | KDM4ETDP1PTGDR2MEN1KMT2A | |
| SCHEMBL17634168 | 0.65 | ALDH1A1 (0.40) | KDM4ECDK4CCND1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173440-B1 | TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS | UPJOHN CO (US) | 2004-09-15 | — | — | EP | claimed |