Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.63 |
| ▸ | NPC1 | O15118 | 9/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852547 | 1.00 | RAB9A (0.63) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL28443608 | 0.87 | RAB9A (0.80) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL5099524 | 0.81 | RAB9A (0.66) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL5099515 | 0.81 | RAB9A (0.66) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL5412134 | 0.81 | RAB9A (0.66) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9170780 | 0.79 | RAB9A (0.89) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9030974 | 0.79 | RAB9A (0.63) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9170782 | 0.79 | RAB9A (0.89) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9000411 | 0.79 | RAB9A (0.69) | RAB9ANPC1KDM4ELMNAPKM | |
| Chimanine B SCHEMBL954132 | 0.79 | KDM4E (0.63) | RAB9ANPC1KDM4ELMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6667338-B2 | For therapy of bacterial infections | ABBOTT LABORATORIES | 2003-12-23 | — | — | US | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |
| US-20020142973-A1 | 9-Amino erythromycin derivatives with antibacterial activity | ABBVIE INC. | 2002-10-03 | — | — | US | disclosed |
| US-20020132782-A1 | 9-amino erythromycin derivatives with antibacterial activity | ABBOTT LABORATORIES | 2002-09-19 | — | — | US | disclosed |
| WO-2002057286-A2 | 9-AMINO ERYTHROMYCIN DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020142973-A1 | 9-Amino erythromycin derivatives with antibacterial activity | MRPL9, MRPL19, MRPL21 | RAB9A 26/4885NPC1 777/4885KDM4E 1397/4885 |
| US-20020132782-A1 | 9-amino erythromycin derivatives with antibacterial activity | MRPL9, MRPL19, MRPL21 | RAB9A 26/4885NPC1 777/4885KDM4E 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.