Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.66 |
| ▸ | NPC1 | O15118 | 9/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099515 | 1.00 | RAB9A (0.66) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL5412134 | 1.00 | RAB9A (0.66) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL28443608 | 0.89 | RAB9A (0.80) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9000411 | 0.81 | RAB9A (0.69) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL6852547 | 0.81 | RAB9A (0.63) | RAB9ANPC1KDM4ELMNAPKM | |
| Chimanine B SCHEMBL954132 | 0.81 | KDM4E (0.63) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9170782 | 0.81 | RAB9A (0.89) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9000404 | 0.81 | RAB9A (0.69) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL6851972 | 0.81 | RAB9A (0.63) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL9170780 | 0.81 | RAB9A (0.89) | RAB9ANPC1KDM4ELMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657034-B2 | Substituted furo[3,2-c]pyridines, thieno[3,2-c]pyridines, thieno[2,3-d]pyridazines and pyrido[3,4-d]pyridazines as phosphodiesterase type 10A inhibitors | AbbVie Deuschland GmbH & Co. KG (DE) | 2017-05-23 | — | — | US | disclosed |
| EP-2776418-B1 | INHIBITORS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE DEUTSCHLAND (DE) | 2017-01-04 | — | — | EP | disclosed |
| US-20160137668-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-05-19 | — | — | US | disclosed |
| US-9273068-B2 | Substituted isoquinolines and phthalazines as inhibitors of phosphodiesterase type 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-03-01 | — | — | US | disclosed |
| EP-2776418-A1 | INHIBITORS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co KG (DE) | 2014-09-17 | — | — | EP | disclosed |
| CN-104053654-A | Inhibitors Of Phosphodiesterase Type 10a | ABBVIE GMBH & CO KG | 2014-09-17 | — | — | CN | disclosed |
| WO-2013068470-A1 | INHIBITORS OF PHOSPHODIESTERASE TYPE 10A | ABBOTT GMBH & CO. KG (DE) | 2013-05-16 | — | — | WO | disclosed |
| US-20130116233-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE INC. (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130116241-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE INC. (US) | 2013-05-09 | — | — | US | disclosed |
| US-7342026-B2 | Substituted quinolines for the treatment of protozoa and retrovirus co-infections | INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (FR) | 2008-03-11 | — | — | US | disclosed |
| US-20070293456-A9 | Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds | HAYFORD ANTHONY | 2007-12-20 | — | — | US | disclosed |
| EP-1351940-B1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF PROTOZOAN AND RETROVIRUS CO-INFECTIONS | INST RECH DEVELOPPEMENT IRD (FR) | 2007-07-25 | — | — | EP | disclosed |
| US-20060160770-A1 | Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds | EAST CAROLINA UNIVERSITY | 2006-07-20 | — | — | US | disclosed |
| WO-2006073938-A2 | METHOD FOR THE SYNTHESIS OF 3-SUBSTITUTED INDOLIZINE AND BENZOINDOLIZINE COMPOUNDS | EAST CAROLINA UNIVERSITY (US) | 2006-07-13 | — | — | WO | disclosed |
| US-20050165052-A1 | Substituted quinolines for the treatment of protozoa and retrovirus co-infections | INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (FR) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137668-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | PDE5A, PDE3A, PDE3B | RAB9A 617/4885NPC1 2314/4885KDM4E 803/4885 |
| US-20130116241-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | PDE5A, PDE3A, PDE3B | RAB9A 617/4885NPC1 2314/4885KDM4E 803/4885 |
| US-20070293456-A9 | Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds | HRH1, IDO1, RNASEH1 | RAB9A 2981/4885NPC1 3135/4885KDM4E 2361/4885 |
| US-20050165052-A1 | Substituted quinolines for the treatment of protozoa and retrovirus co-infections | C1S, C5, NSFL1C | RAB9A 1036/4885NPC1 242/4885KDM4E 3607/4885 |
| US-20060160770-A1 | Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds | HRH1, IDO1, RNASEH1 | RAB9A 2981/4885NPC1 3135/4885KDM4E 2361/4885 |
| US-20130116233-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | PDE5A, PDE3A, PDE2A | RAB9A 483/4885NPC1 2434/4885KDM4E 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.