SCHEMBL6852363

SCHEMBL6852363

[CH2]Cc1ccc(-c2ccncn2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.51
MAPT P10636 1/20 0.38
CYP11B1 P15538 4/20 0.38
CYP11B2 P19099 4/20 0.38
MAPK14 Q16539 4/20 0.36
MAPK10 P53779 2/20 0.36
GSK3B P49841 3/20 0.36
MAPK9 P45984 4/20 0.36
MAPK11 Q15759 2/20 0.36
CAMKK2 Q96RR4 1/20 0.35
HDAC4 P56524 1/20 0.35
MAP4K4 O95819 2/20 0.35
EGFR P00533 2/20 0.35
FRK P42685 2/20 0.35
CSNK1A1 P48729 2/20 0.35
HSP90AA1 P07900 1/20 0.34
MAPK13 O15264 1/20 0.34
RAF1 P04049 1/20 0.34
MAPK12 P53778 1/20 0.34
PRKACA P17612 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9903935 0.83 CYP2D6 (0.60) CYP2D6MAPTMAPK14MAPK10GSK3B
SCHEMBL675705 0.82 CYP2D6 (0.51) CYP2D6MAPTMAPK14MAPK10GSK3B
SCHEMBL30872067 0.81 CYP2D6 (0.51) CYP2D6MAPTCYP11B1CYP11B2MAPK14
SCHEMBL2559714 0.81 CYP2D6 (0.51) CYP2D6MAPTCYP11B1CYP11B2MAPK14
SCHEMBL13637172 0.81 CYP2D6 (0.60) CYP2D6MAPTCYP11B1CYP11B2GSK3B
SCHEMBL24791663 0.81 CYP2D6 (0.51) CYP2D6MAPTCYP11B1CYP11B2MAPK14
SCHEMBL28848117 0.79 HRH3 (0.52) CYP2D6MAPTCYP11B1CYP11B2MAPK14
SCHEMBL8499115 0.77 CYP2D6 (0.53) CYP2D6MAPTMAPK14MAPK10GSK3B
SCHEMBL29415422 0.77 CYP2D6 (0.55) CYP2D6MAPTCYP11B1CYP11B2MAPK14
SCHEMBL13625499 0.77 CYP2D6 (0.51) CYP2D6MAPTGSK3BMAPK9HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1585775-A 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials ORTHO MCNEIL PHARM INC (US) 2005-02-23 CN disclosed
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed