Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30872067 | 1.00 | CYP2D6 (0.51) | CYP2D6LOXL2ADRB2HRH3CYP2A6 | |
| SCHEMBL28848117 | 0.98 | HRH3 (0.52) | CYP2D6LOXL2ADRB2HRH3CYP2A6 | |
| SCHEMBL9903935 | 0.83 | CYP2D6 (0.60) | CYP2D6HSP90AA1MAPK10MAPK14MAPK9 | |
| SCHEMBL28135261 | 0.83 | ADRB2 (0.46) | CYP2D6LOXL2ADRB2HRH3CYP2A6 | |
| SCHEMBL2559714 | 0.81 | CYP2D6 (0.51) | CYP2D6HSP90AA1MAPK10MAPK14MAPK9 | |
| SCHEMBL6852363 | 0.81 | CYP2D6 (0.51) | CYP2D6HSP90AA1MAPK10MAPK14MAPK9 | |
| SCHEMBL13637172 | 0.81 | CYP2D6 (0.60) | CYP2D6MAPK9MAPTCYP11B1CYP11B2 | |
| SCHEMBL15651713 | 0.78 | CYP2D6 (0.51) | CYP2D6HSP90AA1MAPK10MAPK14MAPK9 | |
| SCHEMBL28103664 | 0.78 | CA2 (0.46) | CYP2D6MAPK14 | |
| SCHEMBL8499115 | 0.77 | CYP2D6 (0.53) | CYP2D6HSP90AA1MAPK10MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |