Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 17/20 | 0.58 |
| ▸ | GSK3B | P49841 | 17/20 | 0.58 |
| ▸ | CDK1 | P06493 | 16/20 | 0.58 |
| ▸ | CCNB2 | O95067 | 15/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 15/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 15/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.56 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | CFTR | P13569 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846771 | 0.89 | GSK3A (0.61) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL6851003 | 0.89 | CDK5 (0.61) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1777268 | 0.88 | GSK3A (0.69) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1777538 | 0.85 | GSK3A (0.53) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1779469 | 0.84 | GSK3A (0.69) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1777073 | 0.83 | GSK3A (0.54) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL6852911 | 0.82 | GSK3A (0.67) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1777932 | 0.82 | GSK3A (0.49) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1778251 | 0.81 | GSK3A (0.57) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| Iodide SCHEMBL6852377 | 0.77 | GSK3A (0.58) | GSK3AGSK3BCDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397360-A1 | AZAINDOLES | Aventis Pharma Limited (GB) | 2004-03-17 | — | — | EP | claimed |
| WO-2003000688-A1 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2003-01-03 | — | — | WO | claimed |
| EP-1263759-A2 | AZAINDOLES | Aventis Pharma Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001047922-A2 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2001-07-05 | — | — | WO | disclosed |