Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Argatroban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 7/20 | 0.83 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.78 |
| ▸ | F10 | P00742 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | PLAT | P00750 | 1/20 | 0.78 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.78 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Argatroban SCHEMBL4374 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1145427 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4308143 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4933701 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1145308 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1817517 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3175687 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL29572887 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL23356536 | 0.99 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3135842 | 0.99 | F2 (0.82) | F2PRSS1F10LMNAPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011039290-A1 | A PROCESS FOR THE PREPARATION OF TRANS-(2R)-4-SUBSTITUTED-PIPECOLIC ACIDS AND ESTERS THEREOF, AND INTERMEDIATE COMPOUNDS USED THEREIN | ENANTIA, S.L. (ES) | 2011-04-07 | — | — | WO | disclosed |
| EP-2305646-A1 | A process for the preparation of trans-(2R)-4-substituted-pipecolic acids and esters thereof, and intermediate compounds used therein | Enantia, S.L. (ES) | 2011-04-06 | — | — | EP | disclosed |