Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Argatroban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 7/20 | 0.83 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.78 |
| ▸ | F10 | P00742 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | PLAT | P00750 | 1/20 | 0.78 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.78 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Argatroban SCHEMBL4374 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL6852675 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4308143 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4933701 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1145308 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1817517 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3175687 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL29572887 | 1.00 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL23356536 | 0.99 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3135842 | 0.99 | F2 (0.82) | F2PRSS1F10LMNAPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115554245-A | Argatroban injection liposome and preparation method thereof | 山东新时代药业有限公司 | 2023-01-03 | — | — | CN | disclosed |
| EP-2285799-B1 | METHOD FOR PREPARING ARGATROBAN MONOHYDRATE | LUNDBECK PHARMACEUTICALS ITALY S P A (IT) | 2015-02-25 | — | — | EP | disclosed |
| EP-2687522-A1 | A polymorph of argatroban monohydrate and a process for its synthesis | Lundbeck Pharmaceuticals Italy S.P.A. (IT) | 2014-01-22 | — | — | EP | disclosed |
| US-8378106-B2 | Method for preparing argatroban monohydrate and a process for its synthesis | LUNDBECK PHARMACEUTICALS ITALY S.P.A. (IT) | 2013-02-19 | — | — | US | disclosed |
| US-20120202850-A1 | METHOD FOR TREATING THROMBOSIS AND INHIBITING PLATELET AGGREGATION WITH 21-(S)-ARGATROBAN | TIANJIN WEIJIE TECHNOLOGY CO., LTD. (CN) | 2012-08-09 | — | — | US | disclosed |
| US-20110028726-A1 | METHOD FOR PREPARING ARGATROBAN MONOHYDRATE AND A PROCESS FOR ITS SYNTHESIS | LUNDBECK PHARMACEUTICALS ITALY S.P.A. (IT) | 2011-02-03 | — | — | US | disclosed |
| US-20100016356-A1 | METHOD FOR TREATING THROMBOSIS AND INHIBITING PLATELET AGGREGATION WITH 21-(S)-ARGATROBAN | TIANJIN WEIJIE TECHNOLOGY CO., LTD. (CN) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202850-A1 | METHOD FOR TREATING THROMBOSIS AND INHIBITING PLATELET AGGREGATION WITH 21-(S)-ARGATROBAN | F2, PIGS, PLAT | F2 1/4885PRSS1 144/4885F10 11/4885 |
| US-20100016356-A1 | METHOD FOR TREATING THROMBOSIS AND INHIBITING PLATELET AGGREGATION WITH 21-(S)-ARGATROBAN | F2, PIGS, SERPINC1 | F2 1/4885PRSS1 157/4885F10 9/4885 |
| US-20110028726-A1 | METHOD FOR PREPARING ARGATROBAN MONOHYDRATE AND A PROCESS FOR ITS SYNTHESIS | ASS1, PRMT7, PRMT3 | F2 293/4885PRSS1 1872/4885F10 2500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.