Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.35 |
| ▸ | THRB | P10828 | 5/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855029 | 0.90 | GAA (0.45) | THRATHRBPOLBHSD11B1ESR2 | |
| SCHEMBL6854934 | 0.88 | THRB (0.48) | THRATHRBESR1 | |
| SCHEMBL6854929 | 0.88 | THRB (0.48) | THRATHRBESR1 | |
| SCHEMBL6849370 | 0.82 | THRB (0.49) | THRATHRBPOLBHTR2AAR | |
| SCHEMBL6854434 | 0.81 | THRA (0.48) | THRATHRBPOLBFFAR4 | |
| SCHEMBL6849578 | 0.79 | THRB (0.50) | THRATHRBPOLBESR1GAA | |
| SCHEMBL6849582 | 0.79 | THRB (0.50) | THRATHRBPOLBESR1GAA | |
| SCHEMBL6849344 | 0.76 | THRB (0.55) | THRATHRB | |
| SCHEMBL6855018 | 0.75 | THRB (0.48) | THRATHRBPOLBFFAR4 | |
| SCHEMBL4961949 | 0.73 | POLB (0.43) | THRATHRBSOS1POLBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777442-B2 | Diphenyl derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-17 | — | — | US | disclosed |
| US-20030105078-A1 | Diphenyl derivatives | BAYER AKTIENGESSELLSCHAFT (DE) | 2003-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105078-A1 | Diphenyl derivatives | DPP4, DPP3, DPM1 | THRA 4665/4885THRB 4614/4885SOS1 4540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.