SCHEMBL6853189

SCHEMBL6853189

CCc1c(C(F)(F)F)n[nH]c1C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 6/20 0.38
KDM4E B2RXH2 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
KDM5B Q9UGL1 1/20 0.33
P2RX7 Q99572 3/20 0.33
PRNP P04156 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
PPARG P37231 1/20 0.32
HIF1A Q16665 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
NR2E3 Q9Y5X4 1/20 0.32
NCOR2 Q9Y618 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10447772 0.87 HCAR2 (0.38) HCAR2KDM4EPOLBMAPTKMT2A
SCHEMBL2311797 0.84 HCAR2 (0.40) HCAR2P2RX7PRNPCYP1A2CYP2C9
SCHEMBL22303620 0.82 KDM4C (0.42) KDM4EPOLBMAPTKMT2AKDM5B
SCHEMBL4652482 0.74 HCAR2 (0.43) HCAR2KMT2AP2RX7PRNPCYP1A2
SCHEMBL8324976 0.74 KDM5B (0.33) KDM4EPOLBMAPTKMT2AKDM5B
SCHEMBL4678365 0.73 MAP2K4 (0.48) POLBMAPTP2RX7
SCHEMBL22302563 0.73 GPR35 (0.32) HCAR2MAPT
SCHEMBL9038008 0.73 HCAR2 (0.38) HCAR2KDM4EPRNPCYP1A2CYP2C9
SCHEMBL17224131 0.73 HCAR2 (0.36) HCAR2P2RX7
SCHEMBL3451427 0.72 HCAR2 (0.49) HCAR2KDM4EPOLBMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1427285-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E. I. du Pont de Nemours and Company (US) 2004-06-16 EP disclosed
EP-1416796-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 EP disclosed
WO-2003024222-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E. I. DU PONT DE NEMOURS AND COMPANY (US) 2003-03-27 WO disclosed
WO-2003015518-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed
EP-1265850-A2 INSECTICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2002-12-18 EP disclosed
WO-2001070671-A2 INSECTICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2001-09-27 WO disclosed