SCHEMBL6853470 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	12/20	0.54

▸	PSEN2	P49810	12/20	0.54

▸	APH1B	Q8WW43	12/20	0.54

▸	NCSTN	Q92542	12/20	0.54

▸	APH1A	Q96BI3	12/20	0.54

▸	PSENEN	Q9NZ42	12/20	0.54

▸	KMT2A	Q03164	1/20	0.45

▸	ALDH1A1	P00352	1/20	0.44

▸	CXCR6	O00574	1/20	0.44

▸	KCNH2	Q12809	2/20	0.43

▸	CYP3A4	P08684	1/20	0.43

▸	CYP2C9	P11712	1/20	0.43

▸	CYP2C19	P33261	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6853474	0.92	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853578	0.91	PSEN1 (0.57)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853677	0.88	PSEN1 (0.57)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853634	0.86	PSEN1 (0.57)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853596	0.85	PSEN1 (0.56)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852626	0.85	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853651	0.84	PSEN1 (0.64)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853369	0.83	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853513	0.82	PSEN1 (0.53)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853432	0.81	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011059048-A1	NOVEL AMIDE DERIVATIVE	大日本住友製薬株式会社 (JP)	2011-05-19	—	—	WO	disclosed