SCHEMBL6853578 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	13/20	0.57

▸	PSEN2	P49810	13/20	0.57

▸	APH1B	Q8WW43	13/20	0.57

▸	NCSTN	Q92542	13/20	0.57

▸	APH1A	Q96BI3	13/20	0.57

▸	PSENEN	Q9NZ42	13/20	0.57

▸	PHGDH	O43175	2/20	0.49

▸	KMT2A	Q03164	1/20	0.46

▸	KIF11	P52732	1/20	0.43

▸	MAPT	P10636	1/20	0.42

▸	HTT	P42858	1/20	0.42

▸	SMN1; SMN2	Q16637	1/20	0.42

▸	LDLR	P01130	1/20	0.42

▸	KIT	P10721	1/20	0.42

▸	PCSK9	Q8NBP7	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6853470	0.91	PSEN1 (0.54)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853449	0.89	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853474	0.87	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853471	0.86	PSEN1 (0.65)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852462	0.85	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6854642	0.85	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853933	0.85	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853583	0.81	PSEN1 (0.56)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853369	0.81	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853677	0.80	PSEN1 (0.57)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011059048-A1	NOVEL AMIDE DERIVATIVE	大日本住友製薬株式会社 (JP)	2011-05-19	—	—	WO	disclosed