Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TACR3 | P29371 | 6/20 | 0.47 |
| ▸ | TACR2 | P21452 | 3/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906728 | 0.88 | PDE10A (0.51) | POLBTSHRSMN1; SMN2PDE10ALMNA | |
| SCHEMBL6853322 | 0.88 | TACR3 (0.51) | POLBTSHRPDE10ALMNATACR3 | |
| SCHEMBL4241779 | 0.83 | TACR3 (0.72) | TACR3KCNH2CYP3A4 | |
| SCHEMBL6200397 | 0.81 | PDE10A (0.48) | POLBTSHRPDE10ALMNATACR3 | |
| SCHEMBL4665929 | 0.79 | TACR3 (0.64) | POLBTSHRPDE10ALMNATACR3 | |
| SCHEMBL6853726 | 0.77 | TACR3 (0.60) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL7691041 | 0.77 | PDE10A (0.57) | POLBTSHRPDE10ALMNATACR3 | |
| SCHEMBL8267077 | 0.77 | PDE10A (0.59) | POLBTSHRPDE10ALMNATACR3 | |
| SCHEMBL6853853 | 0.75 | TRPV4 (0.62) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL8268023 | 0.74 | PDE10A (0.56) | POLBTSHRPDE10ALMNATACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | claimed |
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |
| CN-1407850-A | Process for converting storage reserves of dicot seeds into compositions comprising one or more gene products | UNICROP LTD (FI) | 2003-04-02 | — | — | CN | disclosed |
| CN-1406225-A | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists | GLAXO SMITHKLINE S P A (IT) | 2003-03-26 | — | — | CN | disclosed |