Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
| ▸ | TLR2 | O60603 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853686 | 1.00 | CLK4 (0.39) | CLK4DYRK1AADRB2AOC3CYP2A6 | |
| SCHEMBL6853694 | 1.00 | CLK4 (0.39) | CLK4DYRK1AADRB2AOC3CYP2A6 | |
| SCHEMBL6276439 | 0.82 | ADRB2 (0.42) | CLK4ADRB2AOC3CYP2A6CYP19A1 | |
| SCHEMBL6879073 | 0.82 | ADRB2 (0.42) | CLK4ADRB2AOC3CYP2A6CYP19A1 | |
| SCHEMBL6309957 | 0.82 | ADRB2 (0.42) | CLK4ADRB2AOC3CYP2A6CYP19A1 | |
| SCHEMBL6847985 | 0.81 | CLK4 (0.41) | CLK4DYRK1AADRB2AOC3CYP2A6 | |
| SCHEMBL6847988 | 0.81 | CLK4 (0.41) | CLK4DYRK1AADRB2AOC3CYP2A6 | |
| SCHEMBL6854288 | 0.76 | PIK3CD (0.36) | CLK4DYRK1AADRB2AOC3KAT6A | |
| SCHEMBL6854283 | 0.76 | PIK3CD (0.36) | CLK4DYRK1AADRB2AOC3KAT6A | |
| SCHEMBL6854292 | 0.76 | PIK3CD (0.36) | CLK4DYRK1AADRB2AOC3KAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |