Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.58 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PNP | P00491 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | DTYMK | P23919 | 2/20 | 0.47 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.46 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.46 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.46 |
| ▸ | AHCY | P23526 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL264331 | 0.87 | POLB (0.65) | POLBENPP1P2RY1PDE4DPDE3A | |
| SCHEMBL13111573 | 0.85 | POLB (0.69) | POLBENPP1P2RY1SMN1; SMN2DTYMK | |
| SCHEMBL13127042 | 0.85 | POLB (0.69) | POLBENPP1P2RY1SMN1; SMN2DTYMK | |
| SCHEMBL10055622 | 0.85 | POLB (0.69) | POLBENPP1P2RY1SMN1; SMN2DTYMK | |
| SCHEMBL16280905 | 0.85 | POLB (0.69) | POLBENPP1P2RY1SMN1; SMN2DTYMK | |
| SCHEMBL15617973 | 0.85 | POLB (0.68) | POLBENPP1P2RY1HIF1APNP | |
| SCHEMBL6756462 | 0.85 | POLB (0.68) | POLBENPP1P2RY1HIF1APNP | |
| SCHEMBL8007640 | 0.83 | DOT1L (0.65) | P2RY1PDE4DPDE3ASMN1; SMN2DOT1L | |
| SCHEMBL6534168 | 0.82 | POLB (0.60) | POLBENPP1P2RY1HIF1APNP | |
| SCHEMBL5168009 | 0.82 | POLB (0.60) | POLBENPP1P2RY1HIF1APNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828434-B2 | Such as 5-O-4,4'dimethoxytrityl-1,2-dideoxy-1-(o-nitrobenzyl)-D-ribofuranose-3-O-(2 -cyanoethyl-N, N'-diisopropyl) phosphoramidite for enhancing cellular uptake, lipophilicity, and retention of oligonucleotides within; antisense therapy | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |