Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.51 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.61 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.51 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.51 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10055622 | 0.89 | POLB (0.69) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL13127042 | 0.89 | POLB (0.69) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL13111573 | 0.89 | POLB (0.69) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL16280905 | 0.89 | POLB (0.69) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL6853897 | 0.87 | POLB (0.59) | POLBP2RY1ENPP1PDE4DPDE3A | |
| SCHEMBL5168009 | 0.86 | POLB (0.60) | POLBP2RY1ENPP1PDE4DPDE3A | |
| SCHEMBL6534168 | 0.86 | POLB (0.60) | POLBP2RY1ENPP1PDE4DPDE3A | |
| SCHEMBL1883191 | 0.85 | POLB (0.53) | POLBP2RY1ENPP1SRCP2RY2 | |
| SCHEMBL4546151 | 0.84 | POLB (0.81) | POLBP2RY1ENPP1SRCADORA1 | |
| SCHEMBL7882477 | 0.84 | POLB (0.81) | POLBP2RY1ENPP1SRCADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133702-B2 | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20120028248-A1 | ENGINEERED FLUORESCENT DYE LABELED NUCLEOTIDE ANALOGS FOR DNA SEQUENCING | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-7973146-B2 | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-07-05 | — | — | US | disclosed |
| US-20090246791-A1 | ENGINEERED FLUORESCENT DYE LABELED NUCLEOTIDE ANALOGS FOR DNA SEQUENCING | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090246791-A1 | ENGINEERED FLUORESCENT DYE LABELED NUCLEOTIDE ANALOGS FOR DNA SEQUENCING | POLM, POLN, POLB | ADRB2 4315/4885KCNH2 4543/4885POLB 3/4885 |
| US-20120028248-A1 | ENGINEERED FLUORESCENT DYE LABELED NUCLEOTIDE ANALOGS FOR DNA SEQUENCING | POLN, POLM, RNGTT | ADRB2 4314/4885KCNH2 4446/4885POLB 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.