SCHEMBL6854046

SCHEMBL6854046

COc1ccc(N(c2ccc(OC)cc2)c2ccc(-c3ccc(N(c4ccc(OC)cc4)c4ccc([Si](C)(OC)OC)cc4)cc3)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.45
HPGD P15428 3/20 0.45
MAPT P10636 3/20 0.45
ALDH1A1 P00352 2/20 0.45
HSD17B10 Q99714 2/20 0.45
ESR2 Q92731 1/20 0.41
APP P05067 1/20 0.40
ENPP3 O14638 2/20 0.39
USP2 O75604 1/20 0.39
ENPP1 P22413 1/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
NPC1 O15118 5/20 0.38
RAB9A P51151 5/20 0.38
TP53 P04637 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6848121 0.95 CA1 (0.42) KDM4EHPGDMAPTALDH1A1HSD17B10
SCHEMBL6751468 0.86 KDM4E (0.45) KDM4EHPGDMAPTALDH1A1HSD17B10
SCHEMBL6841187 0.85 KDM4E (0.42) KDM4EHPGDMAPTALDH1A1HSD17B10
SCHEMBL12377360 0.84 ALDH1A1 (0.39) KDM4EMAPTALDH1A1APPENPP3
SCHEMBL6846549 0.84 NPC1 (0.35) KDM4EHPGDMAPTALDH1A1HSD17B10
SCHEMBL6848411 0.84 ALDH1A1 (0.39) KDM4EMAPTALDH1A1APPENPP3
SCHEMBL6749627 0.84 KDM4E (0.42) KDM4EHPGDMAPTALDH1A1HSD17B10
SCHEMBL23308936 0.84 ESR2 (0.45) KDM4EHPGDMAPTALDH1A1HSD17B10
SCHEMBL2511345 0.83 ESR2 (0.56) KDM4EHPGDMAPTALDH1A1HSD17B10
SCHEMBL2213226 0.83 ESR2 (0.56) KDM4EHPGDMAPTALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 US disclosed
EP-0861845-B1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL CO (JP) 2003-05-28 EP disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 KDM4E 296/4885HPGD 4102/4885MAPT 1203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.