SCHEMBL6854101

SCHEMBL6854101

O=CC#Cc1ccc2ncccc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.49
POLB P06746 2/20 0.49
RAB9A P51151 2/20 0.49
ACACB O00763 1/20 0.46
ALDH1A1 P00352 5/20 0.46
MAPT P10636 3/20 0.46
ATM Q13315 2/20 0.46
HTT P42858 2/20 0.46
KDM4E B2RXH2 1/20 0.46
TP53 P04637 1/20 0.46
HSP90AA1 P07900 1/20 0.46
HSP90AB1 P08238 1/20 0.46
TSHR P16473 1/20 0.46
CASP1 P29466 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HSD17B10 Q99714 1/20 0.46
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
CASP3 P42574 1/20 0.42
SENP7 Q9BQF6 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6854251 0.87 ALDH1A1 (0.46) NPC1POLBRAB9AACACBALDH1A1
SCHEMBL2009640 0.81 NPC1 (0.57) NPC1POLBRAB9AACACBALDH1A1
SCHEMBL6854298 0.80 ERN1 (0.35) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL6237649 0.79 ALDH1A1 (0.58) RAB9AACACBALDH1A1KDM4ESMN1; SMN2
SCHEMBL6851890 0.78 NPC1 (0.53) NPC1POLBRAB9AACACBALDH1A1
SCHEMBL728191 0.75 CYP1A2 (0.42) RAB9AACACBALDH1A1HSD17B10CYP3A4
SCHEMBL12402769 0.75 ALDH1A1 (0.66) NPC1POLBRAB9AACACBALDH1A1
SCHEMBL30600696 0.75 ALDH1A1 (0.51) NPC1POLBRAB9AACACBALDH1A1
SCHEMBL12324072 0.75 MAPT (0.66) NPC1POLBRAB9AACACBALDH1A1
SCHEMBL5400558 0.74 NPC1 (0.49) NPC1POLBRAB9AACACBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1585775-A 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials ORTHO MCNEIL PHARM INC (US) 2005-02-23 CN disclosed
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed