Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL232457 | 0.80 | ALDH1A1 (0.57) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL27594280 | 0.79 | ALDH1A1 (0.54) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL18253192 | 0.79 | ALDH1A1 (0.65) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL6854101 | 0.79 | NPC1 (0.49) | ALDH1A1ACACBPDGFRBPDGFRARAB9A | |
| SCHEMBL4818276 | 0.77 | ALDH1A1 (0.63) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL7214768 | 0.77 | ALDH1A1 (0.63) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| Formic Acid SCHEMBL30950287 | 0.75 | ALDH1A1 (0.53) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL27614825 | 0.75 | ALDH1A1 (0.59) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL547195 | 0.75 | ALDH1A1 (0.59) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL23781564 | 0.73 | ALDH1A1 (0.71) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1310934-C | Erythromycin 6-O-carbamoylketolide derivatives useful as antibacterial agents | ORTHO MCNEIL PHARM INC (US) | 2007-04-18 | — | — | CN | disclosed |
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-20050014707-A1 | 6,11-4C-bicyclic 9a-azalide derivatives | WANG GUOQIANG (US) | 2005-01-20 | — | — | US | disclosed |
| WO-2005000863-A2 | 6, 11-4C-BICYCLIC 9A-AZALIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| CN-1543472-A | 6-o-carbamoyl ketolide antibacterials | ����-������ҩƷ��˾ | 2004-11-03 | — | — | CN | disclosed |
| WO-2004087728-A2 | 6,11-3C-BICYCLIC 9A-AZALIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6764998-B1 | BACTERICIDES FOR INFECTIONS | ENANTA PHARMACEUTICALS, INC. | 2004-07-20 | — | — | US | disclosed |
| EP-1373289-A1 | 9-AMINO-14-MEMBERED MACROLIDE DERIVED FROM LEUCOMYCIN | Enanta Pharmaceuticals, Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6645941-B1 | Bactericides, antiprotozoa agents | ENANTA PHARMACEUTICALS, INC. | 2003-11-11 | — | — | US | disclosed |
| EP-1343798-A1 | 6-O-CARBAMOYL KETOLIDE DERIVATIVES OF ERYTHROMYCIN USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6613747-B2 | Erythromycins to treat community-acquired pneumonia and upper and lower respiratory tract, skin and soft tissue, hospital-acquired lung, bone and joint infections; Staphyloccus; Enterococcus; Moraxella; Hemophilus; antibiotic resistance | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-09-02 | — | — | US | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |
| US-20030013663-A1 | 6-O-CARBAMOYL KETOLIDE ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-01-16 | — | — | US | disclosed |
| US-6472372-B1 | 6-O-Carbamoyl ketolide antibacterials | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2002-10-29 | — | — | US | disclosed |
| WO-2002081493-A1 | 9-AMINO-14-MEMBERED MACROLIDE DERIVED FROM LEUCOMYCIN | ENANTA PHARMACEUTICALS, INC. (US) | 2002-10-17 | — | — | WO | disclosed |
| US-20020115620-A1 | 6-0-carbamoyl ketolide antibacterials | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-08-22 | — | — | US | disclosed |
| US-6436906-B1 | NOVEL MACROLIDES HAVING ANTIBACTERIAL ACTIVITY TOWARD GRAMPOSITIVE AND GRAMNEGATIVE BACTERIA AS WELL AS MACROLIDE RESISTANT GRAMPOSITIVES | ENANTA PHARMACEUTICALS, INC. | 2002-08-20 | — | — | US | disclosed |
| WO-2002046204-A1 | 6-0-CARBAMOYL KETOLIDE DERIVATIVES OF ERYTHROMYCIN USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014707-A1 | 6,11-4C-bicyclic 9a-azalide derivatives | CYP2C9, CYP2C19, CYP3A7 | ALDH1A1 271/4885CYP1A2 29/4885ACACB 669/4885 |
| US-20030013663-A1 | 6-O-CARBAMOYL KETOLIDE ANTIBACTERIALS | Q6ZSR9, KDM4E, HK1 | ALDH1A1 3560/4885CYP1A2 2899/4885ACACB 2193/4885 |
| US-20020115620-A1 | 6-0-carbamoyl ketolide antibacterials | Q6ZSR9, HK1, KDM4E | ALDH1A1 3629/4885CYP1A2 3028/4885ACACB 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.