Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 7/20 | 0.68 |
| ▸ | CTSL | P07711 | 7/20 | 0.68 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | TUBB | P07437 | 1/20 | 0.68 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.68 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.68 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.68 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.68 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.68 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.68 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.68 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29411863 | 0.81 | HPGD (1.00) | CTSVCTSLHPGDKDM4ELMNA | |
| SCHEMBL367268 | 0.81 | HPGD (1.00) | CTSVCTSLHPGDKDM4ELMNA | |
| SCHEMBL26847008 | 0.79 | CTSV (0.72) | CTSVCTSLHPGDKDM4ELMNA | |
| SCHEMBL312542 | 0.79 | CTSV (0.66) | CTSVCTSLHPGDKDM4ELMNA | |
| SCHEMBL4109053 | 0.79 | NPC1 (0.68) | HPGDKDM4ELMNANPSR1HSD17B10 | |
| SCHEMBL30729276 | 0.79 | NPC1 (0.68) | HPGDKDM4ELMNANPSR1HSD17B10 | |
| SCHEMBL30935678 | 0.79 | HPGD (1.00) | CTSVCTSLHPGDKDM4ELMNA | |
| SCHEMBL6001399 | 0.79 | CTSV (1.00) | CTSVCTSLHPGDKDM4ELMNA | |
| SCHEMBL30462938 | 0.79 | KDM4E (1.00) | CTSVCTSLHPGDKDM4ELMNA | |
| SCHEMBL29411879 | 0.79 | CTSV (1.00) | CTSVCTSLHPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377554-A1 | ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2004-01-07 | — | — | EP | disclosed |
| US-6479504-B1 | USED IN PREVENTATIVE AND THERAPEUTIC TREATMENTS OF AUTOIMMUNE DISEASES AND PHENOMENA, TRANSPLANT REJECTION SUCH AS HOST-VERSUS-GRAFT DISEASE, AND SEPSIS | THE UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2002-11-12 | — | — | US | disclosed |
| WO-2000076982-A1 | ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2000-12-21 | — | — | WO | disclosed |