SCHEMBL6854697

SCHEMBL6854697

COC(=O)[C@@H](NC(=O)C(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccccc1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 4/20 0.50
BACE1 P56817 1/20 0.47
KMT2A Q03164 2/20 0.47
MDM4 O15151 1/20 0.45
TP53 P04637 1/20 0.45
ATM Q13315 1/20 0.45
EPHX2 P34913 1/20 0.45
MDM2 Q00987 1/20 0.44
GPR88 Q9GZN0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20439367 0.87 KMT2A (0.51) CASP3KMT2AMDM4TP53EPHX2
SCHEMBL13688461 0.86 CASP3 (0.49) CASP3BACE1KMT2AMDM4TP53
SCHEMBL8356797 0.86 CASP3 (0.49) CASP3BACE1KMT2AMDM4TP53
SCHEMBL29384904 0.85 KMT2A (0.53) CASP3KMT2AMDM4TP53ATM
SCHEMBL30851468 0.85 KMT2A (0.53) CASP3KMT2AMDM4TP53ATM
SCHEMBL2307241 0.85 KMT2A (0.53) CASP3KMT2AMDM4TP53ATM
SCHEMBL29401270 0.85 KMT2A (0.53) CASP3KMT2AMDM4TP53ATM
SCHEMBL29400606 0.85 KMT2A (0.53) CASP3KMT2AMDM4TP53ATM
SCHEMBL119848 0.85 KMT2A (0.53) CASP3KMT2AMDM4TP53ATM
SCHEMBL118281 0.85 KMT2A (0.53) CASP3KMT2AMDM4TP53ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011055247-A1 A SYNTHETIC CYCLIC DIPEPTIDE AND A PROCESS THEREOF JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) 2011-05-12 WO disclosed