Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851261 | 0.80 | SLC18A3 (0.48) | NPC1 | |
| SCHEMBL7097984 | 0.76 | IGF1R (0.49) | SIGMAR1OPRK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11938903 | 0.76 | SIGMAR1 (0.51) | SIGMAR1OPRK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6857100 | 0.76 | SLC18A3 (0.46) | — | |
| SCHEMBL6855153 | 0.76 | SLC18A3 (0.46) | — | |
| SCHEMBL11932456 | 0.73 | SIGMAR1 (0.46) | SIGMAR1OPRK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11938900 | 0.73 | SIGMAR1 (0.53) | SIGMAR1OPRK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6857568 | 0.72 | SIGMAR1 (0.41) | SIGMAR1OPRK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6857578 | 0.72 | SIGMAR1 (0.41) | SIGMAR1OPRK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6859020 | 0.72 | SIGMAR1 (0.41) | SIGMAR1OPRK1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030139448-A1 | N-(cyclopropylmethyl)azacycloalkanes, compositions containing them and methods of preparation | WARNER-LAMBERT COMPANY | 2003-07-24 | — | — | US | claimed |
| EP-1321461-A1 | N-(Cyclopropylmethyl)-azacycloalkanes, compositions containing them and methods for their preparation | Warner-Lambert Company LLC (US) | 2003-06-25 | — | — | EP | claimed |
| US-6787563-B2 | ANTIDIARRHEA AGENTS; GASTROINTESTINAL DISORDERS | PFIZER INC. | 2004-09-07 | — | — | US | disclosed |
| US-20030139448-A1 | N-(cyclopropylmethyl)azacycloalkanes, compositions containing them and methods of preparation | WARNER-LAMBERT COMPANY | 2003-07-24 | — | — | US | disclosed |
| EP-1321461-A1 | N-(Cyclopropylmethyl)-azacycloalkanes, compositions containing them and methods for their preparation | Warner-Lambert Company LLC (US) | 2003-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139448-A1 | N-(cyclopropylmethyl)azacycloalkanes, compositions containing them and methods of preparation | DNMT1, TPMT, AZI2 | SIGMAR1 142/4885OPRK1 35/4885ALDH1A1 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.