Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | JUN | P05412 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855117 | 1.00 | MAPT (0.55) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL8039279 | 0.91 | MAPT (0.59) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL11864148 | 0.90 | CYP11B2 (0.58) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL7957742 | 0.83 | AKR1C3 (0.63) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL7957744 | 0.83 | AKR1C3 (0.63) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL10991105 | 0.83 | MAPT (0.74) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL10373700 | 0.83 | MAPT (0.74) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL5468466 | 0.83 | ALDH1A1 (0.51) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL5468470 | 0.83 | ALDH1A1 (0.51) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 | |
| SCHEMBL7127950 | 0.81 | MAPT (0.55) | MAPTLMNASMN1; SMN2CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6783557-B1 | NOVEL PYRAZOLO(1,5-A)PYRIMIDINES COMPRISING AT LEAST ONE CATIONIC GROUP | L'OREAL S.A. (FR) | 2004-08-31 | — | — | US | disclosed |